Name | 5,7,8-Trimethoxyflavone |
Synonyms | 5,7,8-Trimethoxyflavone Norwogonin 5,7,8-trimethyl ether 5,7,8-trimethoxy-2-phenyl-chromen-4-one 4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl- |
CAS | 23050-38-6 |
Molecular Formula | C18H16O5 |
Molar Mass | 312.31664 |
Melting Point | 167-168°C |
Boling Point | 507.4±50.0°C |
Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Appearance | Powder |
Storage Condition | 2-8℃ |
In vitro study | 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether; 8, 16, 32, 64 μM; for 24 hours) decreases NO production in a dose-dependent manner in RAW 264.7 macrophages. 5,7,8-Trimethoxyflavone does not change lipopolysaccharide (LPS)-induced (100 ng/mL) cell viability. |
biological activity | 5,7,8-Trimethoxyflavone (Norwogonin 5,7, 8-trimethylther) is derived from Andrographis paniculata and can inhibit NO, the IC50 was 39.1 μm. 5,7,8-Trimethoxyflavone has anti-inflammatory activity. |